Alle publicaties

IDEALHigh-Dose Atorvastatin vs Usual-Dose Simvastatin

Context Evidence suggests that more intensive lowering of low-density lipoprotein cholesterol (LDL-C) than is commonly applied clinically will provide further benefit in stable coronary artery […]

PLUTOEfficacy and Safety of Rosuvastatin Therapy for Children With Familial Hypercholesterolemia

Objectives This study was undertaken to evaluate the efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia. Background Familial hypercholesterolemia is a common […]

Background Inhibition of cholesteryl ester transfer protein (CETP) has been shown to have a sub- stantial effect on plasma lipoprotein levels. We investigated whether torcetrapib, […]

Philip J. Barter, M.D., Ph.D., Mark Caulfield, M.D., M.B., B.S., Mats Eriksson, M.D., Ph.D., Scott M. Grundy, M.D., Ph.D., John J.P. Kastelein, M.D., Ph.D., Michel Komajda, M.D., Jose Lopez-Sendon, M.D., Ph.D., Lori Mosca, M.D., M.P.H., Ph.D., Jean-Claude Tardif, M.D., David D. Waters, M.D., Charles L. Shear, Dr.P.H., James H. Revkin, M.D., Kevin A. Buhr, Ph.D., Marian R. Fisher, Ph.D., Alan R. Tall, M.B., B.S., and Bryan Brewer, M.D., Ph.D., for the ILLUMINATE Investigators

Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia

Context Children with familial hypercholesterolemia have endothelial dysfunction and increased carotid intima-media thickness (IMT), which herald the premature ath- erosclerotic disease they develop later in […]

JUPITERRosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

Background Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, […]

RADIANCE1Effect of Torcetrapib on Carotid Atherosclerosis in Familial Hypercholesterolemia

Background  Torcetrapib, an inhibitor of cholesteryl ester transfer protein, may reduce atheroscle- rotic vascular disease by increasing levels of high-density lipoprotein (HDL) choles- terol. Methods […]

TNT Treating to New TargetsReduction of low-density lipoprotein cholesterol

Background Despite the prognostic value of metabolic syndrome for predicting cardiovascular events, few trials have investigated the effects of statin therapy on cardiovascular morbidity and […]

Efficacy and Safety of Statin Therapy in Children With Familial Hypercholesterolemia

Background A multicenter, randomized, double-blind, placebo-controlled study was conducted to evaluate LDL cholesterol–lowering efficacy, overall safety, and tolerability and the influence on growth and pubertal […]

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