Background Proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases, binds to low-density lipoprotein (LDL) receptors, leading to their accelerated degradation and to increased […]
Background Patients with mixed dyslipidaemia have raised triglycerides, low high-density lipoprotein (HDL) cholesterol, and high low-density lipoprotein (LDL) cholesterol. Augmentation of HDL cholesterol by inhibition […]
Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy Objectives The aim of this study was […]
Effect of rimonabant on carotid intimaemedia thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial Objective The aim of this […]
Background High LDL-cholesterol is a risk factor for atherosclerosis. We aimed to determine whether aggressive cholesterol lowering with statins was more effective than conventional statin […]
Objective: Dalcetrapib increases high-density lipoprotein cholesterol (HDL-C) levels through effects on cholesteryl ester transfer protein (CETP). As part of the dalcetrapib dal-HEART clinical trial programme, […]
Background Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipopro- tein (LDL) cholesterol when added to statin treatment. However, the effect of ezet- imibe on […]
Two-Year Efficacy and Safety of Simvastatin 80 mg in Familial Hypercholesterolemia (The Examination of Probands and Relatives in Statin Studies With Familial Hypercholesterolemia Conventional doses […]