Alle publicaties

Background Proprotein convertase subtilisin/kexin 9 (PCSK9), one of the serine proteases, binds to low-density lipoprotein (LDL) receptors, leading to their accelerated degradation and to increased […]

Evan A. Stein, M.D., Ph.D., Scott Mellis, M.D., Ph.D., George D. Yancopoulos, M.D., Ph.D., Neil Stahl, Ph.D., Douglas Logan, M.D., William B. Smith, M.D., Eleanor Lisbon, M.D., M.P.H., Maria Gutierrez, M.D., Cheryle Webb, M.D., Richard Wu, Ph.D., Yunling Du, Ph.D., Therese Kranz, R.N., M.B.A., Evelyn Gasparino, B.S., and Gary D. Swergold, M.D., Ph.D.

RADIANCE2Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia

Background Patients with mixed dyslipidaemia have raised triglycerides, low high-density lipoprotein (HDL) cholesterol, and high low-density lipoprotein (LDL) cholesterol. Augmentation of HDL cholesterol by inhibition […]

JACCEfficacy and Safety of Mipomersen

Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy Objectives The aim of this study was […]

AUDITOREffect of rimonabant on carotid intimaemedia thickness (CIMT)

Effect of rimonabant on carotid intimaemedia thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial Objective The aim of this […]

ASAPEffect of aggressive versus conventional lipid lowering

Background High LDL-cholesterol is a risk factor for atherosclerosis. We aimed to determine whether aggressive cholesterol lowering with statins was more effective than conventional statin […]

dal-VESSELRationale and design of dal-VESSEL

Objective: Dalcetrapib increases high-density lipoprotein cholesterol (HDL-C) levels through effects on cholesteryl ester transfer protein (CETP). As part of the dalcetrapib dal-HEART clinical trial programme, […]

ENHANCESimvastatin with or without Ezetimibe in Familial Hypercholesterolemia

Background Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density lipopro- tein (LDL) cholesterol when added to statin treatment. However, the effect of ezet- imibe on […]

ExPRESS FHTwo-Year Efficacy and Safety of Simvastatin 80 mg

Two-Year Efficacy and Safety of Simvastatin 80 mg in Familial Hypercholesterolemia (The Examination of Probands and Relatives in Statin Studies With Familial Hypercholesterolemia Conventional doses […]

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